Alterations in Sex Steroid-Binding Protein (SBP), Corticosteroid-Binding Globulin (CBG), and Steroid Hormone Concentrations during Pregnancy in Rhesus Macaques1
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چکیده
منابع مشابه
Levels of sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) messenger ribonucleic acid (mRNAs) in ovarian endometriosis.
Recently, much evidence has indicated that sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) play a role in the intracellular action of sex steroids in target cells. In the present work, expression of SHBG mRNA and CBG mRNA was demonstrated in tissues of human normal endometrium and pelvic endometriosis, using the reverse transcription-polymerase chain reaction (RT-P...
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Glucocorticoids are known to be involved in myocardial regeneration and destruction. Cardiomyocytes are mostly devoid of nuclear glucocorticoid receptors (GRs) and it is generally assumed that effects of adrenal steroids in heart are mediated through the mineralocorticoid receptor (MR). Here we used immunocytochemistry to study localization of corticosteroid binding globulin (CBG) in semithin s...
متن کاملAn amino acid substitution in biobreeding rat corticosteroid binding globulin results in reduced steroid binding affinity.
BioBreeding (BB) rats are derived from an outbred colony of Wistar rats and are used as a model of autoimmune diabetes mellitus. A corticosteroid binding globulin (CBG) variant with reduced affinity for glucocorticoids has now been found in the blood of these animals. The dissociation rate constants of BB CBG for cortisol (4.42 nM) and corticosterone (1.43 nM) are both about 50% higher than tho...
متن کاملSteroid-binding receptors in fungi: implication for systemic mycoses
It has been shown that some of the mycotic infections especially systemic mycoses show increased male susceptibility and some steroids have been known to influence the immune response. Researchers found that some fungi including yeasts use "message molecules" including hormones to elicit certain responses, especially in the sexual cycle, but until recently no evidence was available to...
متن کاملSteroid-protein interactions. XV. Isolation and characterization of corticosteroid-binding globulin from human plasma.
Corticosteroid-binding globulin was isolated from normal human plasma by successive anion exchange chromatography and gel filtration. Ammonium sulfate fractionation was employed as a preliminary step when large volumes were processed. The purification was about 4000-fold. Homogeneity was shown by free boundary, agar and paper electrophoresis, sedimentation velocity, and diffusion. Immunoelectro...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1986
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod35.1.126